Selected article for: "human cell and MERS cov"
Author: Aleksandra Milewska; Ying Chi; Artur Szczepanski; Emilia Barreto-Duran; Kevin Liu; Dan Liu; Xiling Guo; Yiyue Ge; Jingxin Li; Lunbiao Cui; Marek Ochman; Maciej Urlik; Sylwia Rodziewicz-Motowidlo; Fengcai Zhu; Krzysztof Szczubialka; Maria Nowakowska; Krzysztof Pyrc
Title: HTCC as a highly effective polymeric inhibitor of SARS-CoV-2 and MERS-CoV
  • Document date: 2020_3_31
    • ID: 86stuueg_2
    Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.29.014183 doi: bioRxiv preprint vitro using permissive cell lines and ex vivo, using a model of human airway epithelium (HAE). 99 The study showed that the replication of both viruses was efficiently hampered. Overall, our 100 data show that HTCC polymers are potent broad-spectrum anticoronavirals and may be very 101 promising drug candid.....
    Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.29.014183 doi: bioRxiv preprint vitro using permissive cell lines and ex vivo, using a model of human airway epithelium (HAE). 99 The study showed that the replication of both viruses was efficiently hampered. Overall, our 100 data show that HTCC polymers are potent broad-spectrum anticoronavirals and may be very 101 promising drug candidates for SARS-CoV-2 and MERS-CoV. 105 Previously, we showed that HTCC with different degrees of substitution (DSs) is a The study on the MERS-CoV using the Vero cells revealed that all HTCC variants 117 inhibit virus replication to a similar extent (~100-1000-time decrease in viral yields), at non-118 toxic concentration (Figure 1A, C) . The inhibition of the SARS-CoV-2 infection in Vero E6 119 cells was even more pronounced, and all HTCC variants inhibited virus replication by ~10,000 120 times at non-toxic concentration (Figure 1B, C) . In this case, the HTCC-63 was arbitrarily 121 selected for further studies on MERS-CoV, while HTCC-77 was selected for SARS-CoV-2. 122 author/funder. All rights reserved. No reuse allowed without permission.

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