Author: Joseph, J.; Knobler, R. L.; Lubli, F. D.; Hart, M. N.
Title: Differential modulation of MHC class I antigen expression on mouse brain endothelial cells by MHV-4 infection Cord-id: ubbl41d9 Document date: 1989_5_31
ID: ubbl41d9
Snippet: Abstract Virus-induced modulation of mouse cerebral endothelial cell class I and class II antigens by the neurotropic coronavirus, MHV-4 (JHM), was examined by flow cytometry. In susceptible BALB/c, H-2Kd was downregulated, while H-2Dd was upregulated following infection by MHV-4. In contrast, H-2K and H-2D antigens were both upregulated in either MHV-4-susceptible B10.S and (BALB/c × SJL) F1, or MHV-4-resistant SJL-derived cerebral endothelial cells following infection with this virus. Class I
Document: Abstract Virus-induced modulation of mouse cerebral endothelial cell class I and class II antigens by the neurotropic coronavirus, MHV-4 (JHM), was examined by flow cytometry. In susceptible BALB/c, H-2Kd was downregulated, while H-2Dd was upregulated following infection by MHV-4. In contrast, H-2K and H-2D antigens were both upregulated in either MHV-4-susceptible B10.S and (BALB/c × SJL) F1, or MHV-4-resistant SJL-derived cerebral endothelial cells following infection with this virus. Class II antigen expression was unchanged following MHV-4 infection. Virus-induced MHC class I modulation is genetically regulated, and may influence virus clearance by class I-dependent CTL.
Search related documents:
Co phrase search for related documents- additional study and low density: 1
- additional study and low density lipoprotein: 1
Co phrase search for related documents, hyperlinks ordered by date