Author: Duart, Gerard; GarcÃa-Murria, Maria J.; Mingarro, Ismael
Title: The SARS-CoV-2 envelope (E) protein has evolved towards membrane topology robustness Cord-id: ugc82nf3 Document date: 2021_7_1
ID: ugc82nf3
Snippet: -. Single-spanning SARS-CoV-2 envelope (E) protein topology is a major determinant of protein quaternary structure and function. -. Charged residues distribution in E protein sequences from highly pathogenic human coronaviruses (i.e., SARS-CoV, MERS-CoV and SARS-CoV-2) stabilize Nt(out)-Ct(in) membrane topology. -. E protein sequence could have evolved to ensure a more robust membrane topology from MERS-CoV to SARS-CoV and SARS-CoV-2.
Document: -. Single-spanning SARS-CoV-2 envelope (E) protein topology is a major determinant of protein quaternary structure and function. -. Charged residues distribution in E protein sequences from highly pathogenic human coronaviruses (i.e., SARS-CoV, MERS-CoV and SARS-CoV-2) stabilize Nt(out)-Ct(in) membrane topology. -. E protein sequence could have evolved to ensure a more robust membrane topology from MERS-CoV to SARS-CoV and SARS-CoV-2.
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