Recombinant vector vaccines and within-host evolution

James Bull; Scott L. Nuismer; Rustom Antia

Trials were run that contrasted revertant absence versus revertant introduced at 75% of the inoculum -no 270 evolution versus evolution, respectively (Fig. 5) . Absence of the revertant is the baseline against which the 271 effect of evolution can be compared. The horizontal axis varies k X , the parameter for impairment specific to 272 vaccine, and the vertical axis varies k Y , impairment to vector, which affects vaccine and revertant equally. In 273 both panels, increasing impairment against vaccine leads to lower levels of immunity to the vaccine -this 274 is the self-limiting effect of adaptive immunity, which exists even in the absence of evolution. As expected, 275 impairment of vaccine by immunity to vector is also found. vaccine; inoculum size is unchanged. All loss of immunity against vaccine is thus due to revertant in the 280 inoculum and any selective effect from immunity against vaccine.