Author: James Bull; Scott L. Nuismer; Rustom Antia
Title: Recombinant vector vaccines and within-host evolution Document date: 2019_2_8
ID: 3vssgben_3
Snippet: The evolutionary consequences should be the same for both types of inferiority, reducing the long term 185 generation of antigen levels. But the interesting twist is that adaptive immunity to the antigen might feed 186 back negatively on itself to limit its own growth -immunity against a virus is intrinsically inhibitory, so 187 adaptive immunity against the vaccine will limit vaccine growth and thus limit antigen build-up that would 188 fuel fur.....
Document: The evolutionary consequences should be the same for both types of inferiority, reducing the long term 185 generation of antigen levels. But the interesting twist is that adaptive immunity to the antigen might feed 186 back negatively on itself to limit its own growth -immunity against a virus is intrinsically inhibitory, so 187 adaptive immunity against the vaccine will limit vaccine growth and thus limit antigen build-up that would 188 fuel further immunity. One question is whether this self-inhibition is worsened with vaccine evolution.
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