Recombinant vector vaccines and within-host evolution

James Bull; Scott L. Nuismer; Rustom Antia

Evolution can also be reduced by increasing the inoculum size. To achieve a threshold antigen level, a large 324 inoculum requires less growth than a small one. Less growth means less evolution -in the extreme, a large The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It . https://doi.org/10.1101/545087 doi: bioRxiv preprint appreciably increases the magnitude of immunity; a much reduced benefit is seen when revertant frequency is 328 low, likely because there is less evolutionary interference from the revertant. These results hint at a potential Composition of the vaccine has the larger effect for these parameters, as indicated by the contours being more horizontal than vertical. An intrinsic fitness cost of c = 0.1 was set for these trials. Smaller c values would lead to higher vaccine and immunity levels across the graphs.