Author: Lilin Ye; Xiangyu Chen; Ren Li; Zhiwei Pan; Chunfeng Qian; Yang Yang; Renrong You; Jing Zhao; Leiqong Gao; Zhirong Li; Qizhao Huang; Lifan Xu; Jianfang Tang; Qin Tian; Wei Yao; Li Hu; Xiaofeng Yan; Xinyuan Zhou; Pinghuang Liu; Yuzhang Wu; Kai Deng; Zheng Zhang; Yaokai Chen; Zhaohui Qian
Title: Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor Document date: 2020_4_11
ID: 9a2pyqrf_7
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is . https://doi.org/10.1101/2020.04.06.20055475 doi: medRxiv preprint 32D4^mediated! inhibition! of! RBD^hACE2! interaction! was! also! evidenced! by! flow! cytometry!analysis! (Fig.!3c^e) .!Furthermore,!we!determined!the!neutralization!of!these! three! mAbs! using! a! SARS^CoV^2! S! pseudotyped! lentiviral! particle 22 .! In! line! with! ELISA^! and! flow! cytometry^based! blo.....
Document: The copyright holder for this preprint (which was not peer-reviewed) is . https://doi.org/10.1101/2020.04.06.20055475 doi: medRxiv preprint 32D4^mediated! inhibition! of! RBD^hACE2! interaction! was! also! evidenced! by! flow! cytometry!analysis! (Fig.!3c^e) .!Furthermore,!we!determined!the!neutralization!of!these! three! mAbs! using! a! SARS^CoV^2! S! pseudotyped! lentiviral! particle 22 .! In! line! with! ELISA^! and! flow! cytometry^based! blockade! results,! both! 311mab^31B5! and! 311mab^32D4! effectively! neutralized! pseudovirus! entry! to! host! cells! ectopically! expressing! hACE2! (IC 50 =0.0338,! and! 0.0698! μg/ml,! respectively).! As! expected,! 311mab^31B9!clone!failed!to!show!any!neutralization!activities! (Fig.!3f) the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
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