Author: Longlong Si; Haiqing Bai; Melissa Rodas; Wuji Cao; Crystal Yur Oh; Amanda Jiang; Atiq Nurani; Danni Y Zhu; Girija Goyal; Sarah Gilpin; Rachelle Prantil-Baun; Donald E. Ingber
Title: Human organs-on-chips as tools for repurposing approved drugs as potential influenza and COVID19 therapeutics in viral pandemics Document date: 2020_4_14
ID: mrgw2mnx_2
Snippet: Infections by respiratory viruses are currently studied using cultured established cell lines, primary tissue-derived human cells, human organoids, ex vivo human lung tissue cultures, and animal models; however, all of these preclinical models have significant limitations (Supplementary Table 1 ) 9-11 . For example, cultured cell lines often need to be supplemented with exogenous proteases to enable viral propagation, whereas endogenous proteases.....
Document: Infections by respiratory viruses are currently studied using cultured established cell lines, primary tissue-derived human cells, human organoids, ex vivo human lung tissue cultures, and animal models; however, all of these preclinical models have significant limitations (Supplementary Table 1 ) 9-11 . For example, cultured cell lines often need to be supplemented with exogenous proteases to enable viral propagation, whereas endogenous proteases that are naturally expressed by the airway epithelium exert this crucial action in humans 10 . Cell lines and even human cells grown in conventional cultures do not exhibit the highly differentiated tissue structures and functions seen in living human organs. Explant cultures of human respiratory tract tissue circumvent this limitation, but their availability is limited and their viability can only be maintained for short time (4-10 days) 11 . While human lung organoids provide a more author/funder. All rights reserved. No reuse allowed without permission.
Search related documents:
Co phrase search for related documents- airway epithelium and cell line: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- airway epithelium and conventional culture: 1
- airway epithelium and exogenous protease: 1
- airway epithelium and human cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- airway epithelium and human lung: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- animal model and cell line: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15
- animal model and explant culture: 1
- animal model and human cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20
- animal model and human lung: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
- cell line and conventional culture: 1, 2, 3
- cell line and cultured cell line: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- cell line and establish cell line: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
- cell line and explant culture: 1
- cell line and human cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- cell line and human lung: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- conventional culture and human cell: 1, 2, 3, 4, 5, 6, 7, 8
- conventional culture and human lung: 1
- crucial action and human cell: 1, 2
- cultured cell line and human cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
Co phrase search for related documents, hyperlinks ordered by date