364 Obstetrical and neonatal outcomes among pregnancies with SARS-CoV-2

Trahan, Marie Julie; O'Farrell, Patrick; Mitric, Cristina; Desilets, Jade; Bastrash, Marie-Pier; Malhame, Isabelle; El-Messidi, Amira; Abenhaim, Haim A.

Objective: The effects of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) on perinatal outcomes are currently unknown. This study describes obstetrical and neonatal outcomes among patients with SARS-CoV-2 during pregnancy. Study Design: A multicenter retrospective matched cohort study was conducted. Patients who tested positive for SARS-CoV-2 during pregnancy and delivered between March 22 and July 31, 2020 at two tertiary care centers in Montreal, Quebec were matched to patients who did not test positive for SARS-CoV-2 during pregnancy and delivered on the same day and at the same center, at a ratio of 1:5. At both centers, testing was initially restricted to at-risk patients, identified through a screening questionnaire. Subsequently, universal testing was implemented, and all pregnant patients admitted to the hospital were tested. Data were collected through chart review. Result(s): We identified 43 patients with SARS-CoV-2 during pregnancy who delivered during the study period. Among these, 16% (7/43) delivered preterm, compared to 10% (17/163) of controls, 29% (11/38) had intrapartum fetal heart rate tracing abnormalities requiring intervention, compared to 19% of controls (25/129), and 21% (8/38) delivered by emergency cesarean, compared to 19% (25/125) of controls. Infants born to mothers with SARS-CoV-2 had a 13% (6/45) rate of neonatal intensive care admission, compared to 10% (17/164) for controls, and a mean birthweight of 3105 grams, compared to 3279 grams for controls. Conclusion(s): The cesarean delivery rate among patients with SARS-CoV-2 during pregnancy is comparable to our institutional rates. While limited by small sample size, our results suggest that SARS-CoV-2 in pregnancy may be associated with an increased risk of preterm delivery and lower birthweight. These findings may contribute to future meta-analyses, which will be invaluable in evaluating perinatal risks associated with SARS-CoV-2 during pregnancy. Until further data become available, heightened surveillance for pregnancies affected by SARS-CoV-2 is warranted. [Formula presented] [Formula presented]Copyright © 2020