Author: Bing Zhao; Chao Ni; Ran Gao; Yuyan Wang; Li Yang; Jinsong Wei; Ting Lv; Jianqing Liang; Qisheng Zhang; Wei Xu; Youhua Xie; Xiaoyue Wang; Zhenghong Yuan; Junbo Liang; Rong Zhang; Xinhua Lin
Title: Recapitulation of SARS-CoV-2 Infection and Cholangiocyte Damage with Human Liver Organoids Document date: 2020_3_17
ID: edu1zuzt_1
Snippet: Wuhan (China) has caused emergent and significant threats to global public health 1 . 48 The dominant symptoms of coronavirus disease 2019 (COVID-19) are fever and 49 cough 2,3 . However, a proportion of patients showed multi-organ damage and 50 dysfunction 2-4 . Of note, liver damage is emerging as a co-existed symptom reported 51 in patients with COVID-19. A recent epidemiologic study in Shanghai (China) 52 reported that 75 out of 148 (50.7%) C.....
Document: Wuhan (China) has caused emergent and significant threats to global public health 1 . 48 The dominant symptoms of coronavirus disease 2019 (COVID-19) are fever and 49 cough 2,3 . However, a proportion of patients showed multi-organ damage and 50 dysfunction 2-4 . Of note, liver damage is emerging as a co-existed symptom reported 51 in patients with COVID-19. A recent epidemiologic study in Shanghai (China) 52 reported that 75 out of 148 (50.7%) COVID-19 patients had liver function 53 abnormality, indicated by key liver function parameters above the normal range, 54 including alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline 55 phosphatase (ALP) or total bilirubin (TBIL) 5 The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.16.990317 doi: bioRxiv preprint
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