Selected article for: "acute respiratory syndrome and lung concentration"
Author: Veras, Flavio Protasio; Pontelli, Marjorie Cornejo; Silva, Camila Meirelles; Toller-Kawahisa, Juliana E.; de Lima, Mikhael; Nascimento, Daniele Carvalho; Schneider, Ayda Henriques; Caetité, Diego; Tavares, Lucas Alves; Paiva, Isadora M.; Rosales, Roberta; Colón, David; Martins, Ronaldo; Castro, Italo Araujo; Almeida, Glaucia M.; Lopes, Maria Isabel Fernandes; Benatti, Maíra Nilson; Bonjorno, Letícia Pastorelli; Giannini, Marcela Cavichioli; Luppino-Assad, Rodrigo; Almeida, Sérgio Luna; Vilar, Fernando; Santana, Rodrigo; Bollela, Valdes R.; Auxiliadora-Martins, Maria; Borges, Marcos; Miranda, Carlos Henrique; Pazin-Filho, Antônio; da Silva, Luis Lamberti P.; Cunha, Larissa; Zamboni, Dario S.; Dal-Pizzol, Felipe; Leiria, Luiz O.; Siyuan, Li; Batah, Sabrina; Fabro, Alexandre; Mauad, Thais; Dolhnikoff, Marisa; Duarte-Neto, Amaro; Saldiva, Paulo; Cunha, Thiago Mattar; Alves-Filho, José Carlos; Arruda, Eurico; Louzada-Junior, Paulo; Oliveira, Renê Donizeti; Cunha, Fernando Queiroz
Title: SARS-CoV-2–triggered neutrophil extracellular traps mediate COVID-19 pathology
  • Cord-id: qzg03dvg
  • Document date: 2020_9_14
    • ID: qzg03dvg
    Snippet: Severe COVID-19 patients develop acute respiratory distress syndrome that may progress to cytokine storm syndrome, organ dysfunction, and death. Considering that neutrophil extracellular traps (NETs) have been described as important mediators of tissue damage in inflammatory diseases, we investigated whether NETs would be involved in COVID-19 pathophysiology. A cohort of 32 hospitalized patients with a confirmed diagnosis of COVID-19 and healthy controls were enrolled. The concentration of NETs
    Document: Severe COVID-19 patients develop acute respiratory distress syndrome that may progress to cytokine storm syndrome, organ dysfunction, and death. Considering that neutrophil extracellular traps (NETs) have been described as important mediators of tissue damage in inflammatory diseases, we investigated whether NETs would be involved in COVID-19 pathophysiology. A cohort of 32 hospitalized patients with a confirmed diagnosis of COVID-19 and healthy controls were enrolled. The concentration of NETs was augmented in plasma, tracheal aspirate, and lung autopsies tissues from COVID-19 patients, and their neutrophils released higher levels of NETs. Notably, we found that viable SARS-CoV-2 can directly induce the release of NETs by healthy neutrophils. Mechanistically, NETs triggered by SARS-CoV-2 depend on angiotensin-converting enzyme 2, serine protease, virus replication, and PAD-4. Finally, NETs released by SARS-CoV-2–activated neutrophils promote lung epithelial cell death in vitro. These results unravel a possible detrimental role of NETs in the pathophysiology of COVID-19. Therefore, the inhibition of NETs represents a potential therapeutic target for COVID-19.

    Search related documents:
    Co phrase search for related documents
    • absolute number and acute respiratory distress syndrome: 1, 2, 3, 4
    • absolute number and lung damage: 1
    • ace expression and acute lung injury: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
    • ace expression and acute respiratory distress syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
    • ace expression and lung damage: 1
    • active sars replication and acute respiratory distress syndrome: 1
    • active viral infection and acute lung injury: 1
    • active viral infection and acute respiratory distress syndrome: 1, 2
    • active viral infection and lung autopsy: 1
    • active viral infection and lung damage: 1
    • acute lung injury and living cell: 1
    • acute lung injury and lung autopsy: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
    • acute lung injury and lung damage: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • acute respiratory distress syndrome and living cell: 1
    • acute respiratory distress syndrome and lung autopsy: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20
    • acute respiratory distress syndrome and lung damage: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • acute respiratory distress syndrome develop and lung autopsy: 1