Selected article for: "detection sensitivity and SARS detection"
Author: Xiaotian Tan; Cory Lin; Jie Zhang; Maung Kyaw Khaing Oo; Xudong Fan
Title: Rapid and quantitative detection of COVID-19 markers in micro-liter sized samples
  • Document date: 2020_4_22
    • ID: 0tdfvlqd_47
    Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.20.052233 doi: bioRxiv preprint explored 6 . For S1 protein detection, we will improve the detection sensitivity, since the abundance of SARS-CoV-2 S1 may be very low in actual patient samples. Based on our previous publications 17, 28 , the LLOD can be greatly enhanced when we replace the HRP-conjugated detection antibody with a biotinyl.....
    Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.20.052233 doi: bioRxiv preprint explored 6 . For S1 protein detection, we will improve the detection sensitivity, since the abundance of SARS-CoV-2 S1 may be very low in actual patient samples. Based on our previous publications 17, 28 , the LLOD can be greatly enhanced when we replace the HRP-conjugated detection antibody with a biotinylated detection antibody once it become available. For antibody affinity evaluation, we aim to further optimize the assay's protocol (such as adjusting the incubation time and rinsing time) and employ it to evaluate more therapeutic and research use antibodies.

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