Selected article for: "action exact mechanism and exact mechanism"
Author: Maggi, Fabrizio; Rosellini, Alfredo; Spezia, Pietro Giorgio; Focosi, Daniele; Macera, Lisa; Lai, Michele; Pistello, Mauro; de Iure, Antonio; Tomino, Carlo; Bonassi, Stefano; Russo, Patrizia
Title: Nicotine Upregulates ACE2 Expression and Increases Competence for SARS-CoV-2 in human pneumocytes
  • Cord-id: s1jiuige
  • Document date: 2021_3_5
    • ID: s1jiuige
    Snippet: The COVID-19 pandemic has a variable degree of severity according to underlying comorbidities and life-style. Several research groups have reported an association between cigarette smoking and increased severity of COVID-19. The exact mechanism of action is largely unclear. We exposed low ACE2-expressing human pulmonary adenocarcinoma A549 epithelial cells to nicotine and assessed ACE2 expression at different times. We further used the nicotine-exposed cells in a virus neutralisation assay. Nico
    Document: The COVID-19 pandemic has a variable degree of severity according to underlying comorbidities and life-style. Several research groups have reported an association between cigarette smoking and increased severity of COVID-19. The exact mechanism of action is largely unclear. We exposed low ACE2-expressing human pulmonary adenocarcinoma A549 epithelial cells to nicotine and assessed ACE2 expression at different times. We further used the nicotine-exposed cells in a virus neutralisation assay. Nicotine exposure induces rapid and long-lasting increases in gene and protein expression of the SARS-CoV-2 receptor ACE2, which in turn translates into increased competence for SARS-CoV-2 replication and cytopathic effect. These findings show that nicotine worsens SARS-CoV-2 pulmonary infection and have implication for public health policies.

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