Author: Jun Fei; Lin Fu; Ying Li; Hui-Xian Xiang; Ying Xiang; Meng-Die Li; Fang-Fang Liu; De-xiang Xu; Hui Zhao
Title: Reduction of lymphocyte at early stage elevates severity and death risk of COVID-19 patients: a hospital-based case-cohort study Document date: 2020_4_6
ID: 8q1veo3q_22
Snippet: Whereas, increased pulmonary brochovascular shadows, indistinct lung markings and blur, pulmonary consolidation and nodules, and extensive high-density area with obvious lung ground glass shadow in the bilateral lungs were the main lung manifestations in COVID-19 patients with lymphocyte reduction ( Figure 1B) . Besides, the severity of lung damage was scored by two experienced radiologists blind to the clinical data. As shown in Figure 1C -1E, t.....
Document: Whereas, increased pulmonary brochovascular shadows, indistinct lung markings and blur, pulmonary consolidation and nodules, and extensive high-density area with obvious lung ground glass shadow in the bilateral lungs were the main lung manifestations in COVID-19 patients with lymphocyte reduction ( Figure 1B) . Besides, the severity of lung damage was scored by two experienced radiologists blind to the clinical data. As shown in Figure 1C -1E, the results showed that left lung CT score, right lung CT score and bilateral lungs CT score were all evidently increased in patients with lymphocyte reduction (5.0 vs 3.0, 6.0 vs 3.0, 11.0 vs 6.0). Further correlation analysis indicated that lymphocyte count was significantly and negatively associated with CT scores of left lung, right lung and bilateral lung (r=-0.341, P＜ 0.001; r=-0.396, P＜0.001; r=-0.435, P＜0.001 ), respectively.
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