Author: Alpana Waghmare; Elizabeth M Krantz; Subhasish Baral; Emma Vasquez; Tillie Loeffelholz; E. Lisa Chung; Urvashi Pandey; Jane Kuypers; Elizabeth R Duke; Keith R Jerome; Alexander L Greninger; Daniel B Reeves; Florian Hladik; E Fabian Cardozo-Ojeda; Michael Boeckh; Joshua T Schiffer
Title: Reliability of self-sampling for accurate assessment of respiratory virus viral and immunologic kinetics Document date: 2020_4_6
ID: 89s17ytr_11
Snippet: The model suggests that for RSV, an early surge in IFNγ leads to a slight rise in per cell killing 221 rate of infected cells (Fig 4e) leading to a mass elimination of infected cells at a rate of 10 222 million cells per day and a decrease in viral load by a factor of 100-1000. However, this 223 response does not clear the virus. A steady state viral load persists for 4 days until an IL-21 224 mediated response appears. This response kills far m.....
Document: The model suggests that for RSV, an early surge in IFNγ leads to a slight rise in per cell killing 221 rate of infected cells (Fig 4e) leading to a mass elimination of infected cells at a rate of 10 222 million cells per day and a decrease in viral load by a factor of 100-1000. However, this 223 response does not clear the virus. A steady state viral load persists for 4 days until an IL-21 224 mediated response appears. This response kills far more rapidly, but not as intensely as the 225
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