Selected article for: "bioinformatic analysis and immune system"
Author: Gardiner, Erin J.; Cairns, Murray J.; Liu, Bing; Beveridge, Natalie J.; Carr, Vaughan; Kelly, Brian; Scott, Rodney J.; Tooney, Paul A.
Title: Gene expression analysis reveals schizophrenia-associated dysregulation of immune pathways in peripheral blood mononuclear cells
  • Cord-id: qnwgiqfn
  • Document date: 2012_12_4
    • ID: qnwgiqfn
    Snippet: Peripheral blood mononuclear cells (PBMCs) represent an accessible tissue source for gene expression profiling in schizophrenia that could provide insight into the molecular basis of the disorder. This study used the Illumina HT_12 microarray platform and quantitative real time PCR (QPCR) to perform mRNA expression profiling on 114 patients with schizophrenia or schizoaffective disorder and 80 non-psychiatric controls from the Australian Schizophrenia Research Bank (ASRB). Differential expressio
    Document: Peripheral blood mononuclear cells (PBMCs) represent an accessible tissue source for gene expression profiling in schizophrenia that could provide insight into the molecular basis of the disorder. This study used the Illumina HT_12 microarray platform and quantitative real time PCR (QPCR) to perform mRNA expression profiling on 114 patients with schizophrenia or schizoaffective disorder and 80 non-psychiatric controls from the Australian Schizophrenia Research Bank (ASRB). Differential expression analysis revealed altered expression of 164 genes (59 up-regulated and 105 down-regulated) in the PBMCs from patients with schizophrenia compared to controls. Bioinformatic analysis indicated significant enrichment of differentially expressed genes known to be involved or associated with immune function and regulating the immune response. The differential expression of 6 genes, EIF2C2 (Ago 2), MEF2D, EVL, PI3, S100A12 and DEFA4 was confirmed by QPCR. Genome-wide expression analysis of PBMCs from individuals with schizophrenia was characterized by the alteration of genes with immune system function, supporting the hypothesis that the disorder has a significant immunological component in its etiology.

    Search related documents:
    Co phrase search for related documents
    • aberrant expression and acute inflammation: 1
    • aberrant expression and acute respiratory syndrome: 1, 2, 3, 4
    • acetylcholine dopamine and acute inflammation: 1
    • acetylcholine dopamine serotonin and acute inflammation: 1
    • acid induce and activity dependent: 1
    • acid induce and acute respiratory syndrome: 1
    • actin cytoskeleton and acute respiratory syndrome: 1
    • activity dependent and acute inflammation: 1, 2
    • activity dependent and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • acute inflammation and additional gene: 1
    • acute respiratory syndrome and additional gene: 1, 2, 3, 4, 5, 6, 7