Author: Umesh Devappa Suranagi; Harmeet Singh Rehan; Nitesh Goyal
Title: Hydroxychloroquine for the management of COVID-19: Hope or Hype? A Systematic review of the current evidence Document date: 2020_4_22
ID: 0u4ar3b5_11
Snippet: Total 71 articles were identified on initial search of databases as of 15th April, following screening of titles and abstracts and removal of duplicates, the articles of relevance (three invitro studies, 20, 21, 22 two open label non randomized trials, 23,24 two open label RCTs, 25,26 one follow-up study, 27 three reviews, 28,29,30 ten short communications [31] [32] [33] [34] [35] [36] [37] [38] [39] [40] were selected for further data extraction.....
Document: Total 71 articles were identified on initial search of databases as of 15th April, following screening of titles and abstracts and removal of duplicates, the articles of relevance (three invitro studies, 20, 21, 22 two open label non randomized trials, 23,24 two open label RCTs, 25,26 one follow-up study, 27 three reviews, 28,29,30 ten short communications [31] [32] [33] [34] [35] [36] [37] [38] [39] [40] were selected for further data extraction and analyses. We identified 88 clinical trials registered in three clinical trial registry databases. Methodical screening and analysis further yielded 27 RCTs currently undergoing active recruitment. Pre-print servers yielded four clinical studies which included a follow up study, a retrospective safety study, and a rapid review of chloroquine and HCQ in COVID-19 patients.
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