Author: Umesh Devappa Suranagi; Harmeet Singh Rehan; Nitesh Goyal
Title: Hydroxychloroquine for the management of COVID-19: Hope or Hype? A Systematic review of the current evidence Document date: 2020_4_22
ID: 0u4ar3b5_22
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04. 16.20068205 doi: medRxiv preprint Many of the ongoing RCTs conducted are studying the effect of HCQ compared to placebo (NCT04342221, NCT04333654, NCT04332991, NCT04331834), few of the RCTs have parallel design arms of HCQ and Azithromycin (NCT04341727, NCT04341207, NCT04334382). Some RCTs have robust trial designs with quadruple masking.....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04. 16.20068205 doi: medRxiv preprint Many of the ongoing RCTs conducted are studying the effect of HCQ compared to placebo (NCT04342221, NCT04333654, NCT04332991, NCT04331834), few of the RCTs have parallel design arms of HCQ and Azithromycin (NCT04341727, NCT04341207, NCT04334382). Some RCTs have robust trial designs with quadruple masking and strong endpoints (NCT04333654, NCT04332991, NCT04331834). Few RCTs are in advance phases of clinical trials (NCT04316377, NCT04341493) and some studies have large sample size to measure the effect with higher strength of confidence (NCT04328012, NCT04328467). There are studies which are considering the safety endpoints in the main outcome measures (ChiCTR2000029868). Some RCTs are also testing antiretroviral drugs like lopinavir/ritonavir, emtricitabine/tenofovir along with HCQ arm (
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