Author: Lau, Wei Ling; Zuckerman, Jonathan E.; Gupta, Ajay; Kalantar-Zadeh, Kamyar
Title: The COVID-Kidney Controversy: Can SARS-CoV-2 Cause Direct Renal Infection? Cord-id: nk1hi9ol Document date: 2021_2_18
ID: nk1hi9ol
Snippet: CONTEXT: Determining whether SARS-CoV-2 causes direct infection of the kidneys is challenging due to limitations in imaging and molecular tools. SUBJECT OF REVIEW: A growing number of conflicting kidney biopsy and autopsy reports highlight this controversial issue. SECOND OPINION: Based on the collective evidence, therapies that improve hemodynamic stability and oxygenation, or dampen complement activation, are likely to ameliorate acute kidney injury in COVID-19. At this time, whether inhibitio
Document: CONTEXT: Determining whether SARS-CoV-2 causes direct infection of the kidneys is challenging due to limitations in imaging and molecular tools. SUBJECT OF REVIEW: A growing number of conflicting kidney biopsy and autopsy reports highlight this controversial issue. SECOND OPINION: Based on the collective evidence, therapies that improve hemodynamic stability and oxygenation, or dampen complement activation, are likely to ameliorate acute kidney injury in COVID-19. At this time, whether inhibition of viral infection and replication directly modulates kidney damage is inconclusive.
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