Selected article for: "post fusion conformation and SARS spike"
Author: Ivan Mercurio; Vincenzo Tragni; Francesco Busco; Anna De Grassi; Ciro Leonardo Pierri
Title: Protein structure analysis of the interactions between SARS-CoV-2 spike protein and the human ACE2 receptor: from conformational changes to novel neutralizing antibodies
  • Document date: 2020_4_18
    • ID: mswmkgl4_26
    Snippet: The trimer of the SARS-CoV-2 spike protein in post fusion conformation was obtained by duplicating two times the obtained monomer and superimposing the three SARS-CoV-2 spike protein monomers on the three SARS-CoV-1 spike protein monomers reported in 6b3o.pdb (Fig. 2) . The 3D comparative model of SARS-CoV-2 spike protein trimer built by multi-template comparative modeling showed an RMSD lower than 0.5 Ã… with the murine coronavirus spike protein.....
    Document: The trimer of the SARS-CoV-2 spike protein in post fusion conformation was obtained by duplicating two times the obtained monomer and superimposing the three SARS-CoV-2 spike protein monomers on the three SARS-CoV-1 spike protein monomers reported in 6b3o.pdb (Fig. 2) . The 3D comparative model of SARS-CoV-2 spike protein trimer built by multi-template comparative modeling showed an RMSD lower than 0.5 Ã… with the murine coronavirus spike protein in post-fusion conformation (6b3o.pdb). The resulting model (Fig. 2 ) appeared elongated and narrow, according to what observed in fragments of the spike proteins crystallized in post-fusion conformations, whose sequences are reported in Fig. 1 and whose PDB_ID are listed in Supp. Tab. 1. author/funder. All rights reserved. No reuse allowed without permission.

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