Selected article for: "disease outbreak and significant improvement"
Author: Gómez-Mesa, Juan Esteban; Galindo-Coral, Stephania; Montes, Maria Claudia; Martin, Andrés J. Muñoz
Title: THROMBOSIS AND COAGULOPATHY IN COVID-19
  • Cord-id: v5igmg3u
  • Document date: 2020_11_2
    • ID: v5igmg3u
    Snippet: Since December 2019, an outbreak of coronavirus disease 2019 (COVID-19) which initially occurred in the city of Wuhan, located in China's Hubei province, spread around the world and on 11 March 2020, the World Health Organization declared the new Coronavirus disease 2019 (COVID-19) as a pandemic. The presence of comorbidities (e.g.: cardiovascular disease, obesity), SIC score> 4, elevation of D-dimer (> 6 times the normal value), C-reactive protein, troponins and other DIC markers; is associated
    Document: Since December 2019, an outbreak of coronavirus disease 2019 (COVID-19) which initially occurred in the city of Wuhan, located in China's Hubei province, spread around the world and on 11 March 2020, the World Health Organization declared the new Coronavirus disease 2019 (COVID-19) as a pandemic. The presence of comorbidities (e.g.: cardiovascular disease, obesity), SIC score> 4, elevation of D-dimer (> 6 times the normal value), C-reactive protein, troponins and other DIC markers; is associated to a worse prognosis in hospitalized patients with severe COVD-19, reaching a hospital mortality of 42%. Initial anticoagulant treatment with LMWH has been shown to reduce mortality by 48% at 7 days and 37% at 28 days and achieve a significant improvement in the arterial oxygen pressure / inspired fraction of O2 (PaO2 / FiO2) by mitigating the formation of microthrombi and associated pulmonary coagulopathy.

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