Author: Diogo de Moraes; Brunno Vivone Buquete Paiva; Sarah Santiloni Cury; João Pessoa Araújo Junior; Marcelo Alves da Silva Mori; Robson Francisco Carvalho
Title: Prediction of SARS-CoV interaction with host proteins during lung aging reveals a potential role for TRIB3 in COVID-19 Document date: 2020_4_9
ID: hbystii6_3
Snippet: We first identified differentially expressed genes (DEGs) during aging in GTEx human lung samples (release V7) (Data S1). The numbers of significant DEGs increased with aging (Log foldchange ≥ |1| and FDR < 0.05), and individuals of 60-69 year old (yo) presented the highest number of DEGs, in comparison to young adults (20-20 yo) (Figures S1-S2, Table S1 ). Clustering of these DEGs identified age-associated profiles ( Figure 1a ). Among the tra.....
Document: We first identified differentially expressed genes (DEGs) during aging in GTEx human lung samples (release V7) (Data S1). The numbers of significant DEGs increased with aging (Log foldchange ≥ |1| and FDR < 0.05), and individuals of 60-69 year old (yo) presented the highest number of DEGs, in comparison to young adults (20-20 yo) (Figures S1-S2, Table S1 ). Clustering of these DEGs identified age-associated profiles ( Figure 1a ). Among the transcripts translated into proteins predicted as interacting with SARS-CoV, the hyaluronan and proteoglycan link protein 2 (HAPLN2) increased with aging, while tribbles homolog 3 (TRIB3) decreased ( Figure 1b , Table S2 ). HAPLN2
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