Author: Rosanna Asselta; Elvezia Maria Paraboschi; Alberto Mantovani; Stefano Duga
Title: ACE2 and TMPRSS2 variants and expression as candidates to sex and country differences in COVID-19 severity in Italy Document date: 2020_4_2
ID: hrottr01_27
Snippet: Firstly, we looked at the overall burden of deleterious rare variants, using the variant classification described above. Italians had a significant decrease in the burden of deleterious variants compared to Europeans (P=0.039; Table 2A) suggesting that they might have a higher level of TMPRSS2 protein/activity, which in principle should be a risk factor for more severe disease course. This is even more true for the East Asian population, however,.....
Document: Firstly, we looked at the overall burden of deleterious rare variants, using the variant classification described above. Italians had a significant decrease in the burden of deleterious variants compared to Europeans (P=0.039; Table 2A) suggesting that they might have a higher level of TMPRSS2 protein/activity, which in principle should be a risk factor for more severe disease course. This is even more true for the East Asian population, however, in this case, we must consider that the number of individuals over 65 years of age in Italy is more than double the one in the Hubei province (22.7 vs. 10%, respectively) and this is a major determinant of disease lethality.
Search related documents:
Co phrase search for related documents- disease course and high level: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22
- disease course and Hubei province: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- disease course and individual number: 1
- disease course and overall burden: 1
- disease course and protein activity: 1, 2, 3, 4, 5, 6
- disease course and risk factor: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- disease course and severe disease course: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- disease course and severe disease course risk factor: 1, 2, 3, 4, 5, 6, 7, 8
- disease course and significant decrease: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21
- disease lethality and high level: 1
- disease lethality and Hubei province: 1
- disease lethality and protein activity: 1
- disease lethality and risk factor: 1, 2
- high level and major determinant: 1, 2, 3
- high level and overall burden: 1
- high level and protein activity: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
- high level and rare variant: 1
- high level and risk factor: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- high level and severe disease course: 1, 2, 3, 4
Co phrase search for related documents, hyperlinks ordered by date