Author: Rosanna Asselta; Elvezia Maria Paraboschi; Alberto Mantovani; Stefano Duga
Title: ACE2 and TMPRSS2 variants and expression as candidates to sex and country differences in COVID-19 severity in Italy Document date: 2020_4_2
ID: hrottr01_27
Snippet: Firstly, we looked at the overall burden of deleterious rare variants, using the variant classification described above. Italians had a significant decrease in the burden of deleterious variants compared to Europeans (P=0.039; Table 2A) suggesting that they might have a higher level of TMPRSS2 protein/activity, which in principle should be a risk factor for more severe disease course. This is even more true for the East Asian population, however,.....
Document: Firstly, we looked at the overall burden of deleterious rare variants, using the variant classification described above. Italians had a significant decrease in the burden of deleterious variants compared to Europeans (P=0.039; Table 2A) suggesting that they might have a higher level of TMPRSS2 protein/activity, which in principle should be a risk factor for more severe disease course. This is even more true for the East Asian population, however, in this case, we must consider that the number of individuals over 65 years of age in Italy is more than double the one in the Hubei province (22.7 vs. 10%, respectively) and this is a major determinant of disease lethality.
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