Selected article for: "cytokine production and influenza virus infection"
Author: Abusalamah, Hazar; Reel, Jessica M.; Lupfer, Christopher R.
Title: Pyruvate Affects Inflammatory Responses of Macrophages During Influenza A Virus Infection
  • Cord-id: rhgzd3hd
  • Document date: 2020_7_4
    • ID: rhgzd3hd
    Snippet: Pyruvate is the end product of glycolysis and transported into the mitochondria for use in the tricarboxylic acid (TCA) cycle. It is also a common additive in cell culture media. We discovered that inclusion of sodium pyruvate in culture media during infection of mouse bone marrow derived macrophages with influenza A virus impaired cytokine production (IL-6, IL-1β, and TNF-α). Sodium pyruvate did not inhibit viral RNA replication. Instead, the addition of sodium pyruvate alters cellular metabo
    Document: Pyruvate is the end product of glycolysis and transported into the mitochondria for use in the tricarboxylic acid (TCA) cycle. It is also a common additive in cell culture media. We discovered that inclusion of sodium pyruvate in culture media during infection of mouse bone marrow derived macrophages with influenza A virus impaired cytokine production (IL-6, IL-1β, and TNF-α). Sodium pyruvate did not inhibit viral RNA replication. Instead, the addition of sodium pyruvate alters cellular metabolism and diminished mitochondrial reactive oxygen species (ROS) production and lowered immune signaling. Overall, sodium pyruvate affects the immune response produced by macrophages but does not inhibit virus replication.

    Search related documents:
    Co phrase search for related documents
    • acid inducible gene and low immune response: 1
    • acid inducible gene and lung inflammation: 1, 2, 3
    • acid inducible gene retinoic and adaptor recruit: 1
    • acid inducible gene retinoic and low immune response: 1
    • acid inducible gene retinoic and lung inflammation: 1, 2, 3
    • acid synthesis and adenosine triphosphate: 1, 2
    • acid synthesis and lung inflammation: 1
    • additional factor and low overall: 1
    • adenosine triphosphate and lung function: 1
    • adenosine triphosphate and lung inflammation: 1
    • low immune response and lung function: 1