Author: Xiaotian Tan; Cory Lin; Jie Zhang; Maung Kyaw Khaing Oo; Xudong Fan
Title: Rapid and quantitative detection of COVID-19 markers in micro-liter sized samples Document date: 2020_4_22
ID: 0tdfvlqd_29
Snippet: The corresponding results are shown in Fig. 2(B)-(D) . In general, the chemiluminescent intensities are proportional to the concentration of the spiked-in monoclonal antibodies. All these three antibodies are still detectable at 4.7 ng/mL with both types of S1 proteins. For D001 and D006, the signal for both types of S1 proteins is very similar, indicating that the antibodies' binding affinity towards SARS-CoV-2 S1 and SARS-CoV S1 should be very .....
Document: The corresponding results are shown in Fig. 2(B)-(D) . In general, the chemiluminescent intensities are proportional to the concentration of the spiked-in monoclonal antibodies. All these three antibodies are still detectable at 4.7 ng/mL with both types of S1 proteins. For D001 and D006, the signal for both types of S1 proteins is very similar, indicating that the antibodies' binding affinity towards SARS-CoV-2 S1 and SARS-CoV S1 should be very similar (D006 may have a slightly higher affinity towards SARS-CoV-2 S1 than SARS-CoV S1). However, for CR3022, the signal for SARS-CoV-2 S1 is systematically lower than that for SARS-CoV S1, indicative of a weaker affinity of CR3022 towards SARS-CoV-2 S1 than SARS-CoV S1, which agrees with recently published findings about CR3022's binding ability 24, 26 .
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