Author: Xiaotian Tan; Cory Lin; Jie Zhang; Maung Kyaw Khaing Oo; Xudong Fan
Title: Rapid and quantitative detection of COVID-19 markers in micro-liter sized samples Document date: 2020_4_22
ID: 0tdfvlqd_36
Snippet: Based on the studies in the previous sections, it is obvious that a good calibration standard (monoclonal human or humanized IgG towards SARS-CoV-2 S1 protein) is essential for performing quantitative evaluation of the patient's immune response. High affinity antibodies are also essential for building a sensitive SARS-CoV-2 S1 ELISA kit. However, due to nascence of SARS-CoV-2 there is no "gold standard" antibody that can be used in IgG calibratio.....
Document: Based on the studies in the previous sections, it is obvious that a good calibration standard (monoclonal human or humanized IgG towards SARS-CoV-2 S1 protein) is essential for performing quantitative evaluation of the patient's immune response. High affinity antibodies are also essential for building a sensitive SARS-CoV-2 S1 ELISA kit. However, due to nascence of SARS-CoV-2 there is no "gold standard" antibody that can be used in IgG calibration or S1 antigen detection yet. Consequently, it is urgent to find humanized antibodies with high binding affinities.
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