Author: Rashmi Mohanty; Xinquan Liu; Jae You Kim; Xiujuan Peng; Sahil Bhandari; Jasmim Leal; Dhivya Arasappan; Dennis C. Wylie; Tony Dong; Debadyuti Ghosh
Title: Identification of peptide coatings that enhance diffusive transport of nanoparticles through the tumor microenvironment Document date: 2019_6_4
ID: e2uzk4u1_54
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. . https://doi.org/10.1101/659524 doi: bioRxiv preprint brain extracellular space 41 and solid tumor ECM 39 . We conjugated the peptides and PEG coatings to fluorescent carboxylate nanoparticles via standard EDC bioconjugation chemistry. We selected PEG 1 kDa to match with the size of the peptide used in this work. As a result, the size and surface propertie.....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. . https://doi.org/10.1101/659524 doi: bioRxiv preprint brain extracellular space 41 and solid tumor ECM 39 . We conjugated the peptides and PEG coatings to fluorescent carboxylate nanoparticles via standard EDC bioconjugation chemistry. We selected PEG 1 kDa to match with the size of the peptide used in this work. As a result, the size and surface properties of all the particles are similar ( Table 3) , and therefore any change in the diffusivity of the particles is due to their interactions with the tumor tissue. Table 3 . Characterization of the PEG/peptide coated nanoparticle formulations.
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