One health in regenerative medicine: report on the second Havemeyer symposium on regenerative medicine in horses.

Fortier, Lisa Ann; Goodrich, Laurie Ruth; Ribitsch, Iris; Schnabel, Lauren Virginia; Shepard, David Owen; Watts, Ashlee Elizabeth; Whealands Smith, Roger Kenneth

Regenerative medicine is commonly used in human and equine athletes. Potential therapies include culture expanded stem cells, stromal vascular fraction of adipose tissue, platelet-rich plasma, bone marrow concentrate, or autologous conditioned serum. The purpose of this manuscript is to disseminate findings from a workshop on the development of translational regenerative medicine in the equine field. Five themes emerged: stem cell characterization and tenogenic differentiation; interactions between mesenchymal stem cells, other cells and the environment; scaffolds and cell packaging; blood- and bone marrow-based regenerative medicines; clinical use of regenerative therapies. Evidence gained through the use of regenerative medicine applications in the horse should continue to translate to the human patient, bringing novel regenerative therapies to both humans and horses.