Selected article for: "alveolar macrophage and lung macrophage"
Author: Lang, Frederick M.; Lee, Kevin M.-C.; Teijaro, John R.; Becher, Burkhard; Hamilton, John A.
Title: GM-CSF-based treatments in COVID-19: reconciling opposing therapeutic approaches
  • Cord-id: u24g6607
  • Document date: 2020_6_23
    • ID: u24g6607
    Snippet: Therapeutics against coronavirus disease 2019 (COVID-19) are urgently needed. Granulocyte–macrophage colony-stimulating factor (GM-CSF), a myelopoietic growth factor and pro-inflammatory cytokine, plays a critical role in alveolar macrophage homeostasis, lung inflammation and immunological disease. Both administration and inhibition of GM-CSF are currently being therapeutically tested in COVID-19 clinical trials. This Perspective discusses the pleiotropic biology of GM-CSF and the scientific m
    Document: Therapeutics against coronavirus disease 2019 (COVID-19) are urgently needed. Granulocyte–macrophage colony-stimulating factor (GM-CSF), a myelopoietic growth factor and pro-inflammatory cytokine, plays a critical role in alveolar macrophage homeostasis, lung inflammation and immunological disease. Both administration and inhibition of GM-CSF are currently being therapeutically tested in COVID-19 clinical trials. This Perspective discusses the pleiotropic biology of GM-CSF and the scientific merits behind these contrasting approaches.

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