Author: Yafei Wang; Randy Heiland; Morgan Craig; Courtney L. Davis; Ashlee N Ford Versypt; Adrianne Jenner; Jonathan Ozik; Nicholson Collier; Chase Cockrell; Andrew Becker; Gary An; James A. Glazier; Aarthi Narayanan; Amber M Smith; Paul Macklin
Title: Rapid community-driven development of a SARS-CoV-2 tissue simulator Document date: 2020_4_5
ID: lq4tcyh4_149
Snippet: Over time, neighboring cells also become infected. They, too progress towards a higher viral load (increasingly bright shades of yellow). The infection propagates outward from the initially infected cell into the remaining tissue. As each cell's viral load (here measured as number of assembled virions) increases, the viral response model calculates the increasing effect e, and cells have greater probability of apoptosis. Cells nearest to the init.....
Document: Over time, neighboring cells also become infected. They, too progress towards a higher viral load (increasingly bright shades of yellow). The infection propagates outward from the initially infected cell into the remaining tissue. As each cell's viral load (here measured as number of assembled virions) increases, the viral response model calculates the increasing effect e, and cells have greater probability of apoptosis. Cells nearest to the initial site of infection apoptose earliest. As these cells degrade, they are removed from the simulation, leading to the creation of a degraded, cell-free region near the center of the tissue. This degraded region spreads outwards from the initial site of infection over time.
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