Selected article for: "bronchoalveolar lavage fluid and present study"
Author: Cavalli, Eugenio; Petralia, Maria Cristina; Basile, Maria Sofia; Bramanti, Alessia; Bramanti, Placido; Nicoletti, Ferdinando; Spandidos, Demetrios A.; Shoenfeld, Yehuda; Fagone, Paolo
Title: Transcriptomic analysis of COVID-19 lungs and bronchoalveolar lavage fluid samples reveals predominant B cell activation responses to infection
  • Cord-id: rre2sf83
  • Document date: 2020_8_12
    • ID: rre2sf83
    Snippet: The outbreak of the 2019 coronavirus disease (named, COVID-19), caused by the novel SARS-CoV-2 virus, represents a worldwide severe threat to public health. It is of the utmost importance to characterize the immune responses against the SARS-CoV-2 and the mechanisms of hyperinflammation, in order to design better therapeutic strategies for COVID-19. In the present study, a transcriptomic analysis was performed to profile the immune signatures in lung and the bronchoalveolar lavage fluid samples
    Document: The outbreak of the 2019 coronavirus disease (named, COVID-19), caused by the novel SARS-CoV-2 virus, represents a worldwide severe threat to public health. It is of the utmost importance to characterize the immune responses against the SARS-CoV-2 and the mechanisms of hyperinflammation, in order to design better therapeutic strategies for COVID-19. In the present study, a transcriptomic analysis was performed to profile the immune signatures in lung and the bronchoalveolar lavage fluid samples from COVID-19 patients and controls. Our data concordantly revealed increased humoral responses to infection. The elucidation of the host responses to SARS-CoV-2 infection may further improve our understanding of COVID-19 pathogenesis and suggest better therapeutic strategies.

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