Author: Yafei Wang; Randy Heiland; Morgan Craig; Courtney L. Davis; Ashlee N Ford Versypt; Adrianne Jenner; Jonathan Ozik; Nicholson Collier; Chase Cockrell; Andrew Becker; Gary An; James A. Glazier; Aarthi Narayanan; Amber M Smith; Paul Macklin
Title: Rapid community-driven development of a SARS-CoV-2 tissue simulator Document date: 2020_4_5
ID: lq4tcyh4_68
Snippet: In severe cases, a "cytokine storm" of pro-inflammatory cytokines (e.g., IL-2, IL-7, IL-10, G-CSF, IP-10, MCP-1, MIP-1A, and TNF-âº) promotes extensive tissue damage 26 . During influenza virus infection, there is some evidence that ARDS is correlated with the extent of infection in the lower respiratory tract and increased cytokine activity resulting from exposure of the endothelium 32 . Other innate responses, such as neutrophils, have also be.....
Document: In severe cases, a "cytokine storm" of pro-inflammatory cytokines (e.g., IL-2, IL-7, IL-10, G-CSF, IP-10, MCP-1, MIP-1A, and TNF-âº) promotes extensive tissue damage 26 . During influenza virus infection, there is some evidence that ARDS is correlated with the extent of infection in the lower respiratory tract and increased cytokine activity resulting from exposure of the endothelium 32 . Other innate responses, such as neutrophils, have also been shown to be amplified in SARS-CoV-2 25 . These cells generally produce reactive oxygen species (ROS), which can induce the death of infected and healthy cells in the local environment 29 .
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