Author: Carissimo, Guillaume; Xu, Weili; Kwok, Immanuel; Abdad, Mohammad Yazid; Chan, Yi-Hao; Fong, Siew-Wai; Puan, Kia Joo; Lee, Cheryl Yi-Pin; Yeo, Nicholas Kim-Wah; Amrun, Siti Naqiah; Chee, Rhonda Sin-Ling; How, Wilson; Chan, Stephrene; Fan, Bingwen Eugene; Andiappan, Anand Kumar; Lee, Bernett; Rötzschke, Olaf; Young, Barnaby Edward; Leo, Yee-Sin; Lye, David Chien; Renia, Laurent; Ng, Lai Guan; Larbi, Anis; Ng, Lisa FP
Title: Whole blood immunophenotyping uncovers immature neutrophil-to-VD2 T-cell ratio as an early marker for severe COVID-19 Cord-id: uh0fqz9p Document date: 2020_10_16
ID: uh0fqz9p
Snippet: SARS-CoV-2 is the novel coronavirus responsible for the current COVID-19 pandemic. Severe complications are observed only in a small proportion of infected patients but the cellular mechanisms underlying this progression are still unknown. Comprehensive flow cytometry of whole blood samples from 54 COVID-19 patients reveals a dramatic increase in the number of immature neutrophils. This increase strongly correlates with disease severity and is associated with elevated IL-6 and IP-10 levels, two
Document: SARS-CoV-2 is the novel coronavirus responsible for the current COVID-19 pandemic. Severe complications are observed only in a small proportion of infected patients but the cellular mechanisms underlying this progression are still unknown. Comprehensive flow cytometry of whole blood samples from 54 COVID-19 patients reveals a dramatic increase in the number of immature neutrophils. This increase strongly correlates with disease severity and is associated with elevated IL-6 and IP-10 levels, two key players in the cytokine storm. The most pronounced decrease in cell counts is observed for CD8 T-cells and VD2 γδ T-cells, which both exhibit increased differentiation and activation. ROC analysis reveals that the count ratio of immature neutrophils to VD2 (or CD8) T-cells predicts pneumonia onset (0.9071) as well as hypoxia onset (0.8908) with high sensitivity and specificity. It would thus be a useful prognostic marker for preventive patient management and improved healthcare resource management.
Search related documents:
Co phrase search for related documents- absolute cell count and acute respiratory: 1, 2, 3, 4, 5, 6
- absolute cell count and acute respiratory syndrome: 1, 2, 3, 4, 5, 6
- absolute cell count and acute respiratory syndrome coronavirus: 1, 2, 3, 4
- absolute cell count and acute sars infection: 1
- absolute cell count and low grade fever: 1
- absolute cell count and lymphocyte neutrophil: 1, 2, 3, 4, 5, 6, 7, 8
- absolute cell count and lymphocyte neutrophil ratio: 1, 2
- absolute cell count and lymphocyte subset: 1
- absolute count and activation marker: 1, 2
- absolute count and acute ards respiratory distress syndrome: 1, 2, 3, 4
- absolute count and acute healthy: 1
- absolute count and acute infection: 1, 2, 3, 4, 5, 6, 7, 8, 9
- absolute count and acute respiratory: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45
- absolute count and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38
- absolute count and acute respiratory syndrome coronavirus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24
- absolute count and acute sars infection: 1, 2, 3
- absolute count and lymphocyte neutrophil: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60
- absolute count and lymphocyte neutrophil ratio: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37
- absolute count and lymphocyte subset: 1, 2, 3, 4, 5
Co phrase search for related documents, hyperlinks ordered by date