Selected article for: "prediction model and SARS cov"
Author: Zehua Zeng; Zhi Luo; Hongwu Du
Title: Predictions for the binding domain and potential new drug targets of 2019-nCoV
  • Document date: 2020_3_2
    • ID: fvig79k3_32
    Snippet: CoV and the prediction model of 2019-nCoV, and the prediction model with conformation up and down was in line with the actual model of spike of SARS. Therefore, we speculated that 2019-nCoV and SARS may have the same ACE2 binding model. Previous studies built a preliminary 3D model of 2019-nCoV using the Swiss method, and the researchers found that compared with SARS, the 2019-nCOV changed four key bases, but its 3D conformation did not change si.....
    Document: CoV and the prediction model of 2019-nCoV, and the prediction model with conformation up and down was in line with the actual model of spike of SARS. Therefore, we speculated that 2019-nCoV and SARS may have the same ACE2 binding model. Previous studies built a preliminary 3D model of 2019-nCoV using the Swiss method, and the researchers found that compared with SARS, the 2019-nCOV changed four key bases, but its 3D conformation did not change significantly 1 . In our 2019-nCoV 3D model, we found that 2019-nCoV was highly similar to the receptor-binding domain (RBD) domain of SARS-CoV. The main chains of the two protein models were highly coincident and the conformation was in the same direction, and the possibility of combining 2019-nCoV with ACE2 was increased from another perspective.

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