Author: Wen Wen; Wenru Su; Hao Tang; Wenqing Le; Xiaopeng Zhang; Yingfeng Zheng; XiuXing Liu; Lihui Xie; Jianmin Li; Jinguo Ye; Xiuliang Cui; Yushan Miao; Depeng Wang; Jiantao Dong; Chuan-Le Xiao; Wei Chen; Hongyang Wang
Title: Immune Cell Profiling of COVID-19 Patients in the Recovery Stage by Single-Cell Sequencing Document date: 2020_3_27
ID: 8aezcyf9_33
Snippet: infection and the development of adoptive immunity as they synergistically work and induce specific antibodies. Moreover, compared to that in the HCs, B cell activation-related genes, including S100A8, IGLL5, SSR3, IGHA1, XBP1, and MZB1 were primarily expressed in the MPB of the ERS group (Fig. 5D ). We also found similar results in the plasma cells, the antibody-secreting cells (ASC) ( (Fig. 5F ). Single-cell BCR-seq analysis indicated that th.....
Document: infection and the development of adoptive immunity as they synergistically work and induce specific antibodies. Moreover, compared to that in the HCs, B cell activation-related genes, including S100A8, IGLL5, SSR3, IGHA1, XBP1, and MZB1 were primarily expressed in the MPB of the ERS group (Fig. 5D ). We also found similar results in the plasma cells, the antibody-secreting cells (ASC) ( (Fig. 5F ). Single-cell BCR-seq analysis indicated that the IgA isotype was over-represented in COVID-19 patients compared to that in the HC (Fig. 5G ). This corresponded with an increase in the levels of serum IgA, which was also pronounced in other coronavirus infections. Moreover, the ratio of (IgA+IgG+IgE) to (IgD+IgM) increased significantly in the ERS patients and showed a downward trend with recovery time (Fig. 5H ).
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