Recombinant vector vaccines and within-host evolution

James Bull; Scott L. Nuismer; Rustom Antia

A question motivating this analysis was one step deeper in the complexity of these effects: does the self-282 limiting effect of adaptive immunity worsen with evolution? This question can be answered by comparing 283 the self-inhibitory effect between left and right panels as k X is increased. It is seen that the self-inhibitory 284 effect is actually somewhat reduced by the revertant. The revertant lowers the response overall, but when 285 correcting for that difference, the effect of increasing k X is weaker in the right panel than in the left. We 286 attribute this weakening of self-limitation as due to the same effect in Fig. 1 : revertant presence becomes 287 irrelevant as more of the adaptive response to vaccine is controlled by immunity to the vaccine antigen rather than vector -revertant is interfering less.