Author: James Bull; Scott L. Nuismer; Rustom Antia
Title: Recombinant vector vaccines and within-host evolution Document date: 2019_2_8
ID: 3vssgben_39
Snippet: Furthermore, undesirable consequences of vaccine evolution may often be easily remedied by ensuring the 362 frequency of the revertant virus in the inoculum is low and by increasing the size of the inoculum. We 363 also suggest that further gains in vaccine efficacy can be achieved by appropriate engineering of the vaccine 364 antigen, allowing it to elicit immunity that clears the pathogen but not the virus vaccine, although such 365 engineering.....
Document: Furthermore, undesirable consequences of vaccine evolution may often be easily remedied by ensuring the 362 frequency of the revertant virus in the inoculum is low and by increasing the size of the inoculum. We 363 also suggest that further gains in vaccine efficacy can be achieved by appropriate engineering of the vaccine 364 antigen, allowing it to elicit immunity that clears the pathogen but not the virus vaccine, although such 365 engineering may not be easy.
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