Author: AbdelMassih, Antoine; Hozaien, Rafeef; El Shershaby, Meryam; Kamel, Aya; Ismail, Habiba-Allah; Arsanyous, Mariem; El-Husseiny, Nadine; Khalil, Noha; Naeem, Youstina; Fouda, Raghda
Title: The potential role of inhaled nitric oxide for postexposure chemoprophylaxis of COVID-19 Cord-id: s5w7denw Document date: 2021_10_22
ID: s5w7denw
Snippet: BACKGROUND: Several vaccines have been fast-tracked in an attempt to decrease the morbidity and mortality of COVID-19. However, post-exposure prophylaxis has been overlooked in battling COVID-19. MAIN TEXT: Inhaled nitric oxide is a potential tool in post-exposure prophylaxis of COVID-19. It decreases cytosolic calcium levels, which impairs the action of Furin. SARS-CoV-2 uses Furin to replicate in the respiratory tract. SHORT CONCLUSION: Inhaled nitric oxide could decrease the viral load in the
Document: BACKGROUND: Several vaccines have been fast-tracked in an attempt to decrease the morbidity and mortality of COVID-19. However, post-exposure prophylaxis has been overlooked in battling COVID-19. MAIN TEXT: Inhaled nitric oxide is a potential tool in post-exposure prophylaxis of COVID-19. It decreases cytosolic calcium levels, which impairs the action of Furin. SARS-CoV-2 uses Furin to replicate in the respiratory tract. SHORT CONCLUSION: Inhaled nitric oxide could decrease the viral load in the upper respiratory tract, abort clinically symptomatic infection, and prevent subsequent complications. Nitric oxide might be a tool for post-exposure chemoprophylaxis in at-risk groups, especially medical personnel.
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