Selected article for: "aliphatic index and GRAVY hydropathicity grand average"
Author: Saba Ismail; Sajjad Ahmad; Syed Sikander Azam
Title: Immuno-informatics Characterization SARS-CoV-2 Spike Glycoprotein for Prioritization of Epitope based Multivalent Peptide Vaccine
  • Document date: 2020_4_12
    • ID: 3jmo35jc_25
    Snippet: Physicochemical properties of the MEPVC were evaluated in order to assist experimentalists in the field to setup experiments accordingly in vitro and in vivo. The length of MEPVC is spanned across 110 amino acids and has molecular weight of 13.30 kDa. Vaccine construct with weight less than 110 kDa is generally believed to effective vaccine target because of its easier purification. Theoretical pI of MEPVC is 9.8 and aids in locating MEPVC on 2D .....
    Document: Physicochemical properties of the MEPVC were evaluated in order to assist experimentalists in the field to setup experiments accordingly in vitro and in vivo. The length of MEPVC is spanned across 110 amino acids and has molecular weight of 13.30 kDa. Vaccine construct with weight less than 110 kDa is generally believed to effective vaccine target because of its easier purification. Theoretical pI of MEPVC is 9.8 and aids in locating MEPVC on 2D gel. MEPVC aliphatic index is 69.08 projecting the vaccine thermostable at different temperatures. The total number of negatively charged and positively charges residues are 8 and 22, respectively. The grand average of hydropathicity (GRAVY) score computed for the MEPVC is -0.545, illustrating hydrophilic nature of the protein and is likely to interact with water molecules. The estimated half-life of MEPVC in mammalian reticulocytes, in vitro is author/funder. All rights reserved. No reuse allowed without permission.

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