Author: Machill, Antonia; Bals, Robert; Lammert, Frank; Krawczyk, Marcin
Title: Genetic insight into COVIDâ€19 related liver injury: A note on MBOAT7 Cord-id: uwbt4qfd Document date: 2020_12_2
ID: uwbt4qfd
Snippet: with great interest we read the paper by Bianco et al.1 , presenting the association between genetic modifiers of liver injury and outcomes in patients with COVID-19. Whilst Bianco et al.1 showed that the PRS-HFC genetic score does not affect studied phenotypes, they also demonstrated that C3 and AB0 genetic variants are associated with the severity of COVID-19. In this study, we would like to add to these interesting observations and present first data concerning the MBOAT7 polymorphism rs64173
Document: with great interest we read the paper by Bianco et al.1 , presenting the association between genetic modifiers of liver injury and outcomes in patients with COVID-19. Whilst Bianco et al.1 showed that the PRS-HFC genetic score does not affect studied phenotypes, they also demonstrated that C3 and AB0 genetic variants are associated with the severity of COVID-19. In this study, we would like to add to these interesting observations and present first data concerning the MBOAT7 polymorphism rs641738 (which is included among other variants in the PRS-HFS score), a known risk factor for liver steatosis and fibrosis2 .
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