Author: Lu Li; Shuang Li; Manman Xu; Pengfei Yu; Sujun Zheng; Zhongping Duan; Jing Liu; Yu Chen; Junfeng Li
Title: Risk factors related to hepatic injury in patients with corona virus disease 2019 Document date: 2020_3_3
ID: 73gxq2w6_31
Snippet: Previous studies have shown that inflammatory cytokine storm is associated with severe lung injury and adverse outcomes of SARS-CoV or MERS-CoV infection 17, 19, 20 . Inflammatory cytokine storm is an overactive inflammatory response of the human body caused by virus infection, which leads to a persistent activation and reproduction of lymphocytes and macrophages that will secrete huge amount of inflammatory cytokine 21 . Inflammatory cytokine st.....
Document: Previous studies have shown that inflammatory cytokine storm is associated with severe lung injury and adverse outcomes of SARS-CoV or MERS-CoV infection 17, 19, 20 . Inflammatory cytokine storm is an overactive inflammatory response of the human body caused by virus infection, which leads to a persistent activation and reproduction of lymphocytes and macrophages that will secrete huge amount of inflammatory cytokine 21 . Inflammatory cytokine storm not only leads to pulmonary injury, but also the injury of non-pulmonary organs including the liver, kidneys and cardiac muscle. And some studies have found the liver damage is more common in patients with severe pneumonia, which is suspected to be associated with inflammatory factor storm 8, 9 . In our study, patients with liver damage had higher elevated CRP level. As a typical inflammatory index, CRP is an acute phase protein author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
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