Author: Julian Braun; Lucie Loyal; Marco Frentsch; Daniel Wendisch; Philipp Georg; Florian Kurth; Stefan Hippenstiel; Manuela Dingeldey; Beate Kruse; Florent Fauchere; Emre Baysal; Maike Mangold; Larissa Henze; Roland Lauster; Marcus Mall; Kirsten Beyer; Jobst Roehmel; Juergen Schmitz; Stefan Miltenyi; Marcel A Mueller; Martin Witzenrath; Norbert Suttorp; Florian Kern; Ulf Reimer; Holger Wenschuh; Christian Drosten; Victor M Corman; Claudia Giesecke-Thiel; Leif-Erik Sander; Andreas Thiel
Title: Presence of SARS-CoV-2 reactive T cells in COVID-19 patients and healthy donors Document date: 2020_4_22
ID: 164yx77a_10
Snippet: HD for the presence of antibodies specific for the four HCoV (229E, NL63, HKU1, OC43). 130 We detected IgG antibodies against the four HCoV in all tested HD, regardless of the presence 131 of measurable S-reactive CD4 + T cells (Supplementary Figure 4) , showing that S-132 (cross-)reactive CD4 + T cells from HD do not correlate with antibody levels against HCoVs. 133 This is in line with findings from other anti-viral CD4 + T cell responses such .....
Document: HD for the presence of antibodies specific for the four HCoV (229E, NL63, HKU1, OC43). 130 We detected IgG antibodies against the four HCoV in all tested HD, regardless of the presence 131 of measurable S-reactive CD4 + T cells (Supplementary Figure 4) , showing that S-132 (cross-)reactive CD4 + T cells from HD do not correlate with antibody levels against HCoVs. 133 This is in line with findings from other anti-viral CD4 + T cell responses such as in the course 134 of yellow fever vaccination (YFV-17D). Only at very early time points after YFV-17D 135
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