Risk factors for mortality of adult inpatients with Coronavirus disease 2019 (COVID-19): a systematic review and meta-analysis of retrospective studies

Mohammad Parohan; Sajad Yaghoubi; Asal Seraj; Mohammad Hassan Javanbakht; Payam Sarraf; Mahmoud Djalali

is the (which was not peer-reviewed) The copyright holder for this preprint . https://doi.org/10.1101/2020.04.09.20056291 doi: medRxiv preprint 769% (over sevenfold) and 739% (over sevenfold) higher risk of COVID-19 mortality, Findings from the current systematic review and meta-analysis supported the hypothesis that older 161 age (≥65 years old), hypertension, diabetes, COPD and CVDs were associated with higher risk of 162 mortality from COVID-19 infection. To the best of our knowledge, current study is the first meta-163 analysis to summarize earlier retrospective studies on the association between demographic 164 characteristics, comorbidities and risk of death from COVID-19. 165 Our findings are partially in agreement with previous narrative review (16). Previously, older age 166 has been reported as an important risk factor for mortality in SARS and Middle East respiratory 167 syndrome (MERS) (17, 18). The current meta-analysis confirmed that increased age (≥65 years 168 old) was associated with death in COVID-19 patients. The age-dependent defects in B-cell and T-169 cell function and the excess production of type 2 cytokines could lead to prolonged 170 proinflammatory responses and deficiency in control of viral replication, potentially leading to 171 . CC-BY 4.0 International license It is made available under a author/funder, who has granted medRxiv a license to display the preprint in perpetuity.