Author: Leung, Daisy W.; Amarasinghe, Gaya K.
Title: When your cap matters: Structural insights into self vs non-self recognition of 5′ RNA by immunomodulatory host proteins Cord-id: wdx4hbpf Document date: 2016_2_1
ID: wdx4hbpf
Snippet: Cytosolic recognition of viral RNA is important for host innate immune responses. Differential recognition of self vs non-self RNA is a considerable challenge as the inability to differentiate may trigger aberrant immune responses. Recent work identified the composition of the RNA 5′, including the 5′ cap and its methylation state, as an important determinant of recognition by the host. Recent studies have advanced our understanding of the modified 5′ RNA recognition and viral antagonism o
Document: Cytosolic recognition of viral RNA is important for host innate immune responses. Differential recognition of self vs non-self RNA is a considerable challenge as the inability to differentiate may trigger aberrant immune responses. Recent work identified the composition of the RNA 5′, including the 5′ cap and its methylation state, as an important determinant of recognition by the host. Recent studies have advanced our understanding of the modified 5′ RNA recognition and viral antagonism of RNA receptors. Here, we will discuss RIG-I and IFIT proteins as examples of host proteins that detect dsRNA and ssRNA, respectively.
Search related documents:
Co phrase search for related documents- adaptive immune response and long term protection: 1, 2, 3
- adaptive immune response and low affinity: 1
Co phrase search for related documents, hyperlinks ordered by date