Author: Murugesan, Kanagavel; Jagannathan, Prasanna; Pham, Tho D; Pandey, Suchitra; Bonilla, Hector F; Jacobson, Karen; Parsonnet, Julie; Andrews, Jason R; Weiskopf, Daniela; Sette, Alessandro; Pinsky, Benjamin A; Singh, Upinder; Banaei, Niaz
Title: Interferon-gamma release assay for accurate detection of SARS-CoV-2 T cell response Cord-id: v4lpjpc5 Document date: 2020_10_9
ID: v4lpjpc5
Snippet: We investigated feasibility and accuracy of an interferon-gamma release assay (IGRA) for detection of T cell responses to SARS-CoV-2. Whole blood IGRA accurately distinguished between convalescents and uninfected healthy blood donors with a predominantly CD4+ T cell response. SARS-CoV-2 IGRA may serve as a useful diagnostic tool in managing the COVID-19 pandemic.
Document: We investigated feasibility and accuracy of an interferon-gamma release assay (IGRA) for detection of T cell responses to SARS-CoV-2. Whole blood IGRA accurately distinguished between convalescents and uninfected healthy blood donors with a predominantly CD4+ T cell response. SARS-CoV-2 IGRA may serve as a useful diagnostic tool in managing the COVID-19 pandemic.
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