Author: Nila Roy Choudhury; Gregory Heikel; Maryia Trubitsyna; Peter Kubik; Jakub Stanislaw Nowak; Shaun Webb; Sander Granneman; Christos Spanos; Juri Rappsilber; Alfredo Castello; Gracjan Michlewski
Title: RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination Document date: 2017_10_9
ID: ifla4aix_5
Snippet: Importantly, neither T7-TRIM25ΔPRY/SPRY nor T7-TRIM25-PRY/SPRY could bind RNA ( Fig. 1g ). This shows that the TRIM25 CC domain is essential, whereas the isolated PRY/SPRY domain is not sufficient for binding to RNA. These results suggest that TRIM25.....
Document: Importantly, neither T7-TRIM25ΔPRY/SPRY nor T7-TRIM25-PRY/SPRY could bind RNA ( Fig. 1g ). This shows that the TRIM25 CC domain is essential, whereas the isolated PRY/SPRY domain is not sufficient for binding to RNA. These results suggest that TRIM25
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