Author: James Bull; Scott L. Nuismer; Rustom Antia
Title: Recombinant vector vaccines and within-host evolution Document date: 2019_2_8
ID: 3vssgben_10
Snippet: In the trials used for illustration, we allow innate immunity to control the infection and adaptive immunity The dynamics of virus and immunity are shown in the absence of revertant (i.e. no evolution). (Right) The revertant is included, but at two different levels. The solid lines correspond to little evolution: the vaccine has a small cost (intrinsic cost =1%, initial level of W is 0.1 that of initial vaccine, and the mutation rate is 10 − 6 .....
Document: In the trials used for illustration, we allow innate immunity to control the infection and adaptive immunity The dynamics of virus and immunity are shown in the absence of revertant (i.e. no evolution). (Right) The revertant is included, but at two different levels. The solid lines correspond to little evolution: the vaccine has a small cost (intrinsic cost =1%, initial level of W is 0.1 that of initial vaccine, and the mutation rate is 10 − 6 per day). The dotted lines correspond to major evolution: the vaccine has a 20% intrinsic cost, the mutation rate is 10 −3 , and the initial level of the revertant is 10 fold that of the vaccine.
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