Selected article for: "common ancestor and MRCA recent common ancestor"
Author: Juan Angel Patino-Galindo; Ioan Filip; Mohammed AlQuraishi; Raul Rabadan
Title: Recombination and lineage-specific mutations led to the emergence of SARS-CoV-2
  • Document date: 2020_2_18
    • ID: bgdcm1i1_4
    Snippet: In this work, we investigate the evolutionary events that characterize the emergence of SARS-CoV-2. In particular, we identify one recombination event in a region that determines host tropism, the Receptor Binding Domain (RBD) of the Spike gene, which led human SARS and SARS-CoV-2 to share a similar haplotype in the RBD. Through ancestral reconstruction analyses, we also observe that, subsequent to this recombination, a significant enrichment of .....
    Document: In this work, we investigate the evolutionary events that characterize the emergence of SARS-CoV-2. In particular, we identify one recombination event in a region that determines host tropism, the Receptor Binding Domain (RBD) of the Spike gene, which led human SARS and SARS-CoV-2 to share a similar haplotype in the RBD. Through ancestral reconstruction analyses, we also observe that, subsequent to this recombination, a significant enrichment of nonsynymous changes occurred in SARS-CoV-2 after the split from its most recent common ancestor (MRCA) with RaTG13.

    Search related documents:
    Co phrase search for related documents
    • ancestral reconstruction analysis and recent common ancestor: 1
    • ancestral reconstruction and common ancestor: 1, 2, 3, 4, 5, 6, 7
    • ancestral reconstruction and MRCA recent common ancestor: 1
    • ancestral reconstruction and recent common ancestor: 1, 2, 3, 4, 5
    • ancestral reconstruction and recombination event: 1
    • ancestral reconstruction and SARS emergence: 1, 2
    • common ancestor and host tropism: 1
    • common ancestor and MRCA recent common ancestor: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
    • common ancestor and recent common ancestor: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • common ancestor and recombination event: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
    • common ancestor and SARS emergence: 1, 2, 3, 4, 5, 6, 7, 8, 9
    • evolutionary event and recombination event: 1, 2, 3
    • evolutionary event and recombination event identify: 1
    • host tropism and recombination event: 1, 2, 3, 4, 5
    • host tropism and SARS emergence: 1, 2, 3, 4, 5, 6, 7, 8
    • MRCA recent common ancestor and recent common ancestor: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
    • recent common ancestor and recombination event: 1, 2, 3, 4
    • recent common ancestor and SARS emergence: 1, 2, 3, 4, 5, 6
    • recombination event and SARS emergence: 1, 2, 3, 4, 5, 6, 7