Selected article for: "recombination event and SARS emergence"
Author: Juan Angel Patino-Galindo; Ioan Filip; Mohammed AlQuraishi; Raul Rabadan
Title: Recombination and lineage-specific mutations led to the emergence of SARS-CoV-2
  • Document date: 2020_2_18
    • ID: bgdcm1i1_4
    Snippet: In this work, we investigate the evolutionary events that characterize the emergence of SARS-CoV-2. In particular, we identify one recombination event in a region that determines host tropism, the Receptor Binding Domain (RBD) of the Spike gene, which led human SARS and SARS-CoV-2 to share a similar haplotype in the RBD. Through ancestral reconstruction analyses, we also observe that, subsequent to this recombination, a significant enrichment of .....
    Document: In this work, we investigate the evolutionary events that characterize the emergence of SARS-CoV-2. In particular, we identify one recombination event in a region that determines host tropism, the Receptor Binding Domain (RBD) of the Spike gene, which led human SARS and SARS-CoV-2 to share a similar haplotype in the RBD. Through ancestral reconstruction analyses, we also observe that, subsequent to this recombination, a significant enrichment of nonsynymous changes occurred in SARS-CoV-2 after the split from its most recent common ancestor (MRCA) with RaTG13.

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